Publications by authors named "Emmanuela De Lucia Rolfe"
Hum Mol Genet
December 2020
Article Synopsis
- Five genetic variants have been linked to the progression of non-alcoholic fatty liver disease to more severe forms like NASH-fibrosis, with a noteworthy variant identified in the MTARC1 gene.
- The study analyzed metabolomics data from over 18,000 participants across two major studies, focusing on how these genetic variants affect metabolism by measuring levels of 1,449 metabolites.
- Each identified variant showed a unique metabolite profile primarily impacting lipid metabolism, with specific associations, such as the MTARC1 variant correlating with increased sphingomyelin levels, suggesting different biochemical pathways linked to each variant.
