Publications by authors named "Emmanuel de Schlichting"

Background And Objective: Cerebral venous thrombosis (CVT) is a rare but critical condition, particularly in young women, often linked to oral contraceptive use. It can lead to complications like subdural hematoma (SH), which are challenging to diagnose and manage. We report the case of a 39-year-old woman who presented with severe headaches and neurological symptoms, leading to a diagnosis of chronic SH and CVT, associated with long-term oral contraceptive use.

View Article and Find Full Text PDF

Background: Magnetic resonance-guided focused ultrasound (MRgFUS) trials targeting the anterior limb of the internal capsule have shown promising results. We evaluated the long-term safety and efficacy of MRgFUS capsulotomy in patients with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD).

Methods: This phase 1, single-center, open-label study recruited patients with treatment-resistant OCD and MDD.

View Article and Find Full Text PDF

Background And Objectives: Aneurysmal surgery is technically complex, and surgeon experience is an important factor in therapeutic success, but training young vascular neurosurgeons has become a complex paradigm. Despite new technologies and simulation models, cadaveric studies still offer an incomparable training tool with perfect anatomic accuracy, especially in neurosurgery. The use of human placenta for learning and improving microsurgical skills has been previously described.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focused on analyzing neuro-oncology care pathways for adolescents and young adults aged 13-29 at Grenoble Alpes University Hospital, following French health guidelines, and included patients diagnosed with primary brain tumors (excluding certain types) between 2013 and 2019.
  • - Out of 60 patients examined, it was found that not all key stages of care were completed, but those managed in a pediatric oncology department showed better collaboration and access to a dedicated AYA support team.
  • - The research emphasized the need for enhanced interdisciplinary cooperation between adult and pediatric services, recommending increased vigilance in key care steps to improve overall patient care for AYA populations and proposing an ideal neuro-oncology care pathway for this group.
View Article and Find Full Text PDF

Background: Sophysa SM8 is widely used by neurosurgeons in France. Published studies report shunt malfunction rates in adults between 18% and 29%. However, these studies included multiple valve types and thus entailed a serious confounding factor.

View Article and Find Full Text PDF

Objective: The authors analyzed the current-intensity thresholds for electrostimulation of language fasciculi and the possible consequences of threshold variability on brain mapping.

Methods: A prospective protocol of subcortical electrostimulation was used in 50 patients undergoing brain mapping, directly stimulating presumed language fasciculi identified by diffusion tensor imaging.

Results: The stimulation-intensity thresholds for identification of language fasciculi varied among patients (mean minimum current intensity of 4.

View Article and Find Full Text PDF

Degenerative cervical myelopathy (DCM) is characterized by a progressive deterioration in spinal cord function. Its evaluation requires subjective clinical examination with wide interobserver variability. Objective quantification of spinal cord function remains imprecise, even though validated myelopathy-grading scales have emerged and are now widely used.

View Article and Find Full Text PDF

Objective: Shunt malfunctions seem more frequent in children (44 to 81%) than in adults (18 to 29%). Because of discrepancies between studies, it is not possible to affirm this disparity. The objective was to verify whether the incidence of cerebrospinal fluid (CSF) shunt malfunctions is higher in children than adults.

View Article and Find Full Text PDF

Background: Intracranial aneurysms (IAs) can be treated through endovascular treatment (EVT) or microsurgery (MS). Treated IAs can recanalize, which can lead to rupture or retreatment.

Objective: The aim of our study was to evaluate the natural history of previously treated IA, by evaluating the risk of rupture and the risk of retreatment.

View Article and Find Full Text PDF

Premature infants with severe germinal matrix intraventricular hemorrhage (IVH) are at high risk of posthemorrhagic ventricular dilation and hydrocephalus (Video 1). We report the case of a 3-month-old premature infant referred for posthemorrhagic multilocated hydrocephalus. He presented with somnolence, hypotonia, and a bulging fontanelle.

View Article and Find Full Text PDF

Premature infants with severe germinal matrix/intraventricular hemorrhage are at high risk of posthemorrhagic ventricular dilation and hydrocephalus (Video 1). We report a 4-month-old premature infant with grade III intraventricular hemorrhage and compartmentalized hydrocephalus with an unusual craniospinal cyst. The cyst extended anteriorly from the mesencephalon to the posterior wall of C6, causing severe compression of the brainstem and spinal cord.

View Article and Find Full Text PDF

Stereo-electro-encephalography (SEEG) is an invasive, surgical, and electrophysiological method for three-dimensional registration and mapping of seizure activity in drug-resistant epilepsy. It allows the accurate analysis of spatio-temporal seizure activity by multiple intraparenchymal depth electrodes. The technique requires rigorous non-invasive pre-SEEG evaluation (clinical, video-EEG, and neuroimaging investigations) in order to plan the insertion of the SEEG electrodes with minimal risk and maximal recording accuracy.

View Article and Find Full Text PDF

Giant perivascular spaces (PVS) are rare, CSF-filled, dilated cavities lined by the pia mater that are most often asymptomatic radiological findings but can sometimes cause neurological symptoms. We present two exceptional cases of secondary focal dystonia induced by the mass effect on the basal ganglia caused by giant diencephalic PVSs. In both cases, we chose a surgical stereotactic drainage approach as a treatment strategy that allowed controlling the movement disorders.

View Article and Find Full Text PDF

Background: Endovascular procedures have become more and more prevalent in both general vascular and neurosurgical practices. Because these procedures rely on real-time bidimensional control through fluoroscopic guidance, they can be prone to spatial misplacement in the third dimension when not controlled in 2 different radiologic planes.

Case Description: We report a unique complication of an iliocaval vessel stenting procedure with misplacement of a venous stent in the spinal canal.

View Article and Find Full Text PDF

Background: Frameless robotic-assisted surgery is an innovative technique for deep brain stimulation (DBS) that has not been assessed in a large cohort of patients.

Objective: To evaluate accuracy of DBS lead placement using the ROSA® robot (Zimmer Biomet) and a frameless registration.

Methods: All patients undergoing DBS surgery in our institution between 2012 and 2016 were prospectively included in an open label single-center study.

View Article and Find Full Text PDF

Background: Battery life of the most commonly used implantable pulse generators in deep brain stimulation is limited. Device replacement is costly and may expose patients to additional risks. Driven by the observation that in our experience newer generation devices seemed to need earlier replacement than the older generation, we aimed to retrospectively analyze the battery life of two generations of non-rechargeable devices, manufactured by a single company (Medtronic, USA).

View Article and Find Full Text PDF

We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who underwent bilateral STN-DBS. Normalized brain structure volumes and cortical thicknesses were measured on pre-operative T1-weighted MRI.

View Article and Find Full Text PDF
Article Synopsis
  • This study compared the foramen magnum area (FMA) and posterior cranial fossa volume (PCFV) in relation to ossification of cranial base synchondroses in healthy children.
  • It found that boys have significantly larger FMA and PCFV compared to girls, with growth occurring in two phases: rapid growth followed by stabilization, with girls' growth phases being shorter and occurring earlier.
  • The research also established a timeline for the closure of various synchondroses, indicating that earlier closure in girls contributes to their smaller FMA and PCFV at birth.
View Article and Find Full Text PDF