PROM2 overexpression induces metastatic potential through epithelial-to-mesenchymal transition and ferroptosis resistance in human cancers.

Introduction: Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified prominin-2 (PROM2) as a biomarker predictive of distant metastases and decreased survival, thus providing a promising bio-target. In this translational study, we set out to decipher the biological roles of PROM2 during the metastatic process and resistance to cell death, in particular for metastatic melanoma.

Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment.

Background: Clear-cell renal cell carcinomas (ccRCCs) are malignant tumors with high metastatic potential and resistance to treatments occurs almost constantly. Compared to primary tumors, there are still limited genomic data that has been obtained from metastatic samples.

Methods: We aimed to characterize metastatic ccRCC by way of whole-genome analyses of metastatic formalin-fixed samples, using OncoScan technology.

Severe post-renal acute kidney injury, post-obstructive diuresis and renal recovery.

Unlabelled: Study Type--Therapy (case series) Level of Evidence 4. What's known on the subject? and What does the study add? The pathophysiology of post-renal acute kidney injury (PR-AKI), i.e.

Novel FH mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma.

Background: Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant disorder predisposing humans to cutaneous and uterine leiomyomas; in 20% of affected families, type 2 papillary renal cell cancers (PRCCII) also occur with aggressive course and poor prognosis. HLRCC results from heterozygous germline mutations in the tumour suppressor fumarate hydratase (FH) gene.

Methods: As part of the French National Cancer Institute (INCa) 'Inherited predispositions to kidney cancer' network, sequence analysis and a functional study of FH were preformed in 56 families with clinically proven or suspected HLRCC and in 23 patients with isolated PRCCII (5 familial and 18 sporadic).

No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome.

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumor predisposition syndrome caused by heterozygous germline mutations in the fumarate hydratase (FH) gene. Cutaneous and uterine leiomyomas are the most common clinical manifestations of HLRCC, whereas only approximately 20% of the families display renal cell cancer (RCC). The number of RCC cases in these families varies from one to five.

[Bladder cancer in neurological patients: analysis of a single-centre series].

Objective: To report the prevalence, aetiologies and course of bladder cancer in our population of neurological patients.

Materials And Methods: The case files of 1825 neurological patients followed in our department between 2000 and 2006 were retrospectively reviewed. The following data were recorded in patients with bladder tumour: age, gender smoking, aetiology of the neurological disease, voiding mode, history of neurogenic bladder, mode of discovery, histological type, grade, TNM stage, treatment and outcome.

[Surgical learning curve for creation of vascular accesses for haemodialysis: value of medico-radio-surgical collaboration].

Introduction: Creation of a vascular access (VA) for haemodialysis is a surgical procedure which comprises a failure rate related to the quality of the vessels and the operator's experience. The authors report the first 2 years of a young urologist's experience with this procedure in a local hospital in collaboration with the nephrology team.

Patients And Methods: Patients undergoing creation of VA were divided into 2 chronological groups.

[Medical management of post-obstruction diuresis syndromes].

The presence of urinary tract obstruction affects the proximal urinary tract by altering renal filtration and excretion functions, resulting in accumulation of electrolytes. Many pathophysiological mechanisms are also involved during obstruction and may be expressed secondarily. For example, relief of obstruction, which restores free flow of urine, is accompanied by marked diuresis and electrolyte disorders.

[Emphysematous cystitis complicating non-conservative total hysterectomy for ovarian cancer].

The authors report a case of emphysematous cystitis in a 50-year-old woman treated by corticosteroids, occurring 1 month after hysterectomy for locally advanced ovarian cancer. Although the patient presented a vesico-vaginal fistula, the presence of air in the bladder wall and only in the bladder lumen, confirmed the diagnosis of emphysematous cystitis. Despite intensive care and surgery with colostomy and Mikulicz drainage associated with urinary diversion (transparietal bladder catheter on one side and cutaneous ureterostomy on the other side), the patient died on day 10 in a context of sepsis.