Publications by authors named "Emmanuel Uche"

The study explains the time-quantile-frequency adjustments of green growth to energy vulnerability, energy uncertainties, and geopolitical risks (GPR) in the United States (US). Novel insights with notable policy implications emerged following the empirical analysis of monthly data spanning 2000 m1-2022 m12. The study implemented the Wavelet Quantile Correlation (WQC), Wavelet Quantile Granger Causality, and the Rolling Windows Wavelet Quantile Granger Causality to understand the dynamics among the variables.

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The theoretical premises of open trade predict that open economies would benefit more from trade than those in autarky. Empirical findings for Nigeria are mixed both for macro-based studies and those devoted to sectoral investigations. In this paper, we re-evaluate the evidence on trade openness's impact on the performance of small- and medium-scale enterprises (SMEs) in Nigeria.

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Irrespective of the vast array of empirical evaluations pertaining to the environmental Kuznets curve (EKC) hypothesis, both for India and other countries, previous studies, amid divergent submissions, inadvertently failed to highlight the relevant threshold that ensures significant reductions in environmental decay. Additionally, the implications of environmental-control technology on environmental quality are also lacking mostly in the context of Indian economy. Thus, this study enlists environmental-control technology and other relevant factors over the period 1980-2018 and employs the novel multiple threshold nonlinear ARDL technique, a model rarely applied in previous studies for updated empirical narratives.

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The pervasive effects of the novel coronavirus (COVID-19) have put the world to test. Its effects permeate all facets of life including healthcare services and food supplies. However, most empirical studies failed to investigate its effects on the prices of food and healthcare services, which by all standards, are essential commodities.

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Previous studies failed to account for the effects of major, minor and moderate changes in financial development on environmental sustainability in Nigeria. To provide this necessary fresh evidence, the current study applied the recently proposed multiple threshold nonlinear autoregressive distributed lag model for the provision of such information. Quarterly data series from 2000Q1 to 2018Q4 obtained from various data hosts were used for empirical analysis.

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Background: Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens. Several studies have investigated the relationship between genetic polymorphisms of CYP1B1 and breast cancer risk with inconsistent results. A G --> C transversion polymorphism in the heme-binding region in codon 432 of the gene results in amino acid change (Val --> Leu); the Leu allele display increased catalytic efficiency for 4-hydroxylation of estradiol in some experimental systems.

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Background: Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin receptor have recently been implicated in processes leading to breast cancer initiation and progression in animal models and humans. An A to G transition mutation in codon 223 in exon 6 of the leptin receptor gene, resulting in glutamine to arginine substitution (Gln223Arg), lies within the first of two putative leptin-binding regions and may be associated with impaired signaling capacity of the leptin receptor.

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The recent upsurge in global obesity and the recognition of the role of metabolic syndrome and other correlates of obesity in the etiology of breast cancer and other chronic diseases has created the impetus for renewed interest in the role of anthropometric measures in breast cancer risk. This case-control study was designed to evaluate the role of anthropometric variables in breast cancer susceptibility in an indigenous sub-Saharan African population drawn from midwestern and southeastern Nigeria, a population grossly underreported in the global epidemiologic literature. Study participants were 250 women with breast cancer who were receiving treatment in the surgical outpatient clinics and surgical wards of four university teaching hospitals located in midwestern and southeastern Nigeria, while the controls were 250 age-matched women without breast cancer or other malignant diseases being treated for other surgical diseases in the same institutions between September 2002 and April 2004.

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This study evaluated the potential risk factors for breast cancer in Nigerian women using a case-control design of 250 women with breast cancer and their age-matched female controls. Both cases and controls were recruited from 4 University Teaching Hospitals in Midwestern and Southeastern Nigeria. Data on the clinical and epidemiological characteristics were collected using interviewer-administered structured questionnaires.

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Background: Breast cancer is the most common cancer and the leading cause of cancer related deaths in women worldwide. The incidence of the disease is increasing globally and this increase is occurring at a faster rate in population groups that hirtherto enjoyed low incidence. This study was designed to evaluate the role of a simple tandem repeat polymorphism (STRP) in the aromatase (CYP19) gene in breast cancer susceptibility in Nigerian women, a population of indigenous sub-Saharan African ancestry.

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In this case-control study based on 250 women with breast cancer and 250 age-matched controls, we sought to evaluate the role of four polymorphic variants in the CYP1A1 gene in breast cancer susceptibility in Nigerian women. Heterozygosity for the CYP1A1 M1 genotype (CYP1A1 M1 [T/C]) was associated with a 21% reduced risk of breast cancer (OR = 0.79, 95% CI 0.

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