Publications by authors named "Emmanuel Rwamutwe"
Article Synopsis
- The study investigates the unique immunopathology of SARS-CoV-2 infection in Uganda, revealing critical biological signatures associated with severe COVID-19, including immune cell activation and protein synthesis impairments.
- Findings indicate that immune responses, particularly involving IL-7, IL-15, and lymphotoxin-α, play significant roles in COVID-19 severity, especially in patients with HIV.
- The research emphasizes the importance of understanding local viral and host factors in developing targeted therapies for severe COVID-19 in sub-Saharan Africa, suggesting avenues for broader immunotherapy strategies.
Among a prospective cohort of children and adults admitted to a national COVID-19 treatment unit in Uganda from March to December 2020, we characterized the epidemiology of and risk factors for severe illness. Across two epidemic phases differentiated by varying levels of community transmission, the proportion of patients admitted with WHO-defined severe COVID-19 ranged from 5% (7/146; 95% CI: 2-10) to 33% (41/124; 95% CI: 25-42); 21% (26/124; 95% CI: 14-29%) of patients admitted during the peak phase received oxygen therapy. Severe COVID-19 was associated with older age, male sex, and longer duration of illness before admission.
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