An exploratory study of the mandate and functions of national pharmaceutical services units: global trends and the cases of Côte d'Ivoire, Kenya, and Nepal.

Background: National pharmaceutical services units (NPSUs) - organisational units within the central government usually responsible for pharmaceutical services and management - have an increasingly narrow mandate. Anecdotal evidence points to an increasing focus, almost exclusively, on logistics management, while pharmaceutical care and policy oversight have become fragmented. This study examined NPSUs' current functions and mandates, and proposed what should be the critical functions and roles of these units going forward.

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned.

Uganda has been implementing the Global Health Security Agenda (GHSA) since 2015 to build its capacity according to . The country remains prone to outbreaks, with more than 20 disease outbreaks reported in the past five years, including Ebola virus disease, Crimean-Congo haemorrhagic fever, Marburg haemorrhagic fever, measles, yellow fever, coronavirus disease 2019 (COVID-19), and cholera. Antimicrobial resistance (AMR) is an ongoing challenge.

Moving from assessments to implementation: promising practices for strengthening multisectoral antimicrobial resistance containment capacity.

Background: Antimicrobial resistance (AMR) poses a global threat to human, animal, and environmental health. AMR is a technical area in the Global Health Security Agenda initiative which uses the Joint External Evaluation tool to evaluate national AMR containment capacity. This paper describes four promising practices for strengthening national antimicrobial resistance containment capacity based on the experiences of the US Agency for International Development's Medicines, Technologies, and Pharmaceutical Services Program work with 13 countries to implement their national action plans on AMR in the areas of multisectoral coordination, infection prevention and control, and antimicrobial stewardship.

Computational design and molecular modeling of the interaction of nicotinic acid hydrazide nickel-based complexes with HS gas.

The application of nickel complexes of nicotinic acid hydrazide ligand as a potential gas-sensor and adsorbent material for HS gas was examined using appropriate density functional theory (DFT) calculations with the ωB97XD/Gen/6-311++G(d,p)/LanL2DZ method. The FT-IR spectrum of the synthesized ligand exhibited a medium band at 3178 cm attributed to (NH) stretching vibrations and strong bands at 1657 and 1600 cm corresponding to the presence of (C[double bond, length as m-dash]O) and (C[double bond, length as m-dash]N) vibration modes. In the spectrum of the nickel(ii) complex, the (C[double bond, length as m-dash]O) and (C[double bond, length as m-dash]N) vibration bands experience negative shifts to 1605 cm and 1580 cm, respectively, compared to the ligand.

A homochiral coordination polymer of cobalt(II) and L-serine.

A one-dimensional chiral cobalt(II) coordination polymer, namely, catena-poly[[[(S)-2-amino-3-hydroxypropanoato-κN,O]cobalt(II)]-μ-(S)-2-amino-3-hydroxypropanoato-κO,O:N,O], [Co(CHNO)] or Δ-[Co(L-Ser-κN,O)] (L-Ser = L-serine) (1), has been synthesized and characterized using elemental and thermal analyses, IR spectroscopy and single-crystal and powder X-ray diffraction techniques. The asymmetric unit of 1 consists of two serine anions which are coordinated to a Co ion to give three chelate rings. These extend the structure into a helical chain with pendant chelate rings which participate in interchain hydrogen bonding.

Success or Failure of Chiral Crystallization of Similar Heterocyclic Compounds.

Single crystals of two achiral and planar heterocyclic compounds, CHHO() and CHNO (), recrystallized from ethanol, were characterized by single crystal X-ray analysis, respectively, and chiral crystallization was observed only for as 222 (# 19), whereas it was not observed for 2/c (# 14). In , as a monohydrate, the hydrogen bonds were pronounced around the water of crystallization (O4), and the planar cyclic sites were arranged in parallel to slightly tilted positions. On the other hand, an anhydride formed a dimer by hydrogen bonds between adjacent molecules in the crystal, which were aggregated by van der Waals forces and placed in parallel planar cyclic sites.

Integrating pharmaceutical systems strengthening in the current global health scenario: three 'uncomfortable truths'.

The response to emergency public health challenges such as HIV, TB, and malaria has been successful in mobilising resources and scaling up treatment for communicable diseases. However, many of the remaining challenges in improving access to and appropriate use of medicines and services require pharmaceutical systems strengthening. Incorporating pharmaceutical systems strengthening into global health programmes requires recognition of a few 'truths'.

Two 1D homochiral heterometallic chains: crystal structures, spectra, ferroelectricity and ferromagnetic properties.

Two new homo chiral Cu-Ln (Ln = Gd and Ho) compounds bearing a chiral Schiff base ligand (1,3)-',''-bis[3-methoxysalicylidene]-1,3-diamino-1,2,2-trimethylcyclopentane (HL) have been synthesized and characterized by elemental analysis, IR spectroscopic and single-crystal X-ray diffraction techniques. The compounds were found to exhibit 1D zig-zag skeletons with double μ-1,5 bridging dicyanamide anions. Circular dichroism (CD) spectra have been used to verify their chiroptical activities.

Di-mu-acetato-bis[(2-acetylpyridine thiosemicarbazonato)zinc(II)].

The title compound, [Zn2(C2H3O2)2(C8H9N4S)2], is a centrosymmetric dinuclear molecule with two acetate bridging ligands in a syn-syn arrangement. The Zn(II) atom is five-coordinated in a trigonal-bipyramidal configuration by three thiosemicarbazone atoms (two N and one S) and by an O atom from each of the two acetate groups.