Management of neonatal retro-auricular embryonal rhabdomyosarcoma - Case report.

Introduction: Rhabdomyosarcoma (RMS) arises from mesenchymal cells committed to skeletal muscle. It is the most frequent soft-tissue sarcoma in children and makes up 5% of all pediatric malignant tumors. In this population, there are two main histological forms, which are the embryonal or the alveolar RMS.

Folate-equipped nanolipoplexes mediated efficient gene transfer into human epithelial cells.

Since recombinant viral vectors have been associated with serious side effects, such as immunogenicity and oncogenicity, synthetic delivery systems represent a realistic alternative for achieving efficacy in gene therapy. A major challenge for non-viral nanocarriers is the optimization of transgene expression in the targeted cells. This goal can be achieved by fine-tuning the chemical carriers and the adding specific motifs to promote cellular penetration.

[Care of the tracheostomy in brain injury patients].

The evolution of a patient suffering from a serious head injury can require the placement of a tracheotomy. This helps with respirator weaning and usually enables the patient to be moved from the neurosurgical intensive care ward to the neurosurgery ward. Patients fitted with a tracheotomy will therefore be cared for by post-intensive care neurological rehabilitation departments.

Folate-equipped pegylated archaeal lipid derivatives: synthesis and transfection properties.

We have previously shown that synthetic archaeal lipid analogues are useful vectors for drug/gene delivery. We report herein the synthesis and gene transfer properties of a series of novel di- and tetraether-type archaeal derivatives with a poly(ethylene glycol) (PEG) chain and further equipped with a folic acid (FA) group. The synthetic strategy and the purification by dialysis ensured complete removal of free FA.