Publications by authors named "Emmanuel Jhj Wiertz"
Article Synopsis
- Human colorectal cancer-derived cancer-associated fibroblasts (CAFs) can cross-present neoantigens, which enhances their ability to interact with tumor-specific CD8+ T cells compared to normal fibroblasts.
- The study utilized advanced genetic techniques and assays to identify the molecular mechanisms involved, particularly highlighting the role of the lysosomal protease cathepsin S.
- Results showed that interaction between CAFs and CD8+ T cells can lead to reduced T cell activation and increased exhaustion, suggesting that CAFs may negatively impact tumor immunity.
T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses have evolved several mechanisms to avoid recognition, many of which target the MHC-I antigen-processing pathway.
View Article and Find Full Text PDFIslet transplantation is a promising therapy for type 1 diabetes, but graft function and survival are compromised by recurrent islet autoimmunity. Immunoprotection of islets will be required to improve clinical outcome. We engineered human β cells to express herpesvirus-encoded immune-evasion proteins, "immunevasins.
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