Publications by authors named "Emmanuel E Hape"

Background: The Anopheles funestus group includes at least 11 sibling species, with Anopheles funestus Giles being the most studied and significant malaria vector. Other species, like Anopheles parensis, are understudied despite their potential role in transmission. This article provides insights into the biology and insecticide susceptibility of An.

View Article and Find Full Text PDF

Background: Malaria transmission in Tanzania is driven by mosquitoes of the Anopheles gambiae complex and Anopheles funestus group. The latter includes An. funestus s.

View Article and Find Full Text PDF
Article Synopsis
  • Anopheles funestus, a key malaria vector in East and Southern Africa, is less understood in terms of ecology and resistance to insecticides compared to other mosquitoes, leading to a large-scale study in Tanzania on its genetic resistance and susceptibility to insecticides.
  • The study used bioassays across nine regions to examine resistance, identifying universal resistance to pyrethroids that could be reversed with piperonyl-butoxide, and variable resistance to carbamates and DDT.
  • Geographic patterns showed distinct distribution of genetic markers associated with resistance, with the most complex resistance landscape found in the Tanganyika district of western Tanzania, highlighting the need for tailored vector control strategies.
View Article and Find Full Text PDF

Background: In south-eastern Tanzania where insecticide-treated nets have been widely used for >20 years, malaria transmission has greatly reduced but remains highly heterogenous over small distances. This study investigated the seasonal prevalence of sporozoite infections in the two main malaria vector species, and for 34 months, starting January 2018 to November 2020.

Methods: Adult mosquitoes were collected using CDC-light traps and Prokopack aspirators inside local houses in Igumbiro and Sululu villages, where earlier surveys had found very high densities of .

View Article and Find Full Text PDF

Background: It is often assumed that the population dynamics of the malaria vector Anopheles funestus, its role in malaria transmission and the way it responds to interventions are similar to the more elaborately characterized Anopheles gambiae. However, An. funestus has several unique ecological features that could generate distinct transmission dynamics and responsiveness to interventions.

View Article and Find Full Text PDF

Supplementary tools are required to address the limitations of insecticide-treated nets (ITNs) and indoor residual spraying (IRS), which are currently the core vector control methods against malaria in Africa. The eave ribbons technology exploits the natural house-entry behaviours of major malaria vectors to deliver mosquitocidal or repellent actives around eave spaces through which the Anopheles mosquitoes usually enter human dwellings. They confer protection by preventing biting indoors and in the peri-domestic outdoor spaces, and also killing a significant proportion of the mosquitoes.

View Article and Find Full Text PDF

Background: Wild populations of Anopheles mosquitoes are generally thought to mate outdoors in swarms, although once colonized, they also mate readily inside laboratory cages. This study investigated whether the malaria vectors Anopheles funestus and Anopheles arabiensis can also naturally mate inside human dwellings.

Method: Mosquitoes were sampled from three volunteer-occupied experimental huts in a rural Tanzanian village at 6:00 p.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the challenges in colonizing the malaria vector Anopheles funestus from Tanzania (FUTAZ), by comparing its characteristics to a successfully colonized strain from Mozambique (FUMOZ).
  • Wild FUTAZ mosquitoes demonstrated significantly lower reproductive success and survival rates in lab conditions compared to FUMOZ, with fewer eggs laid and a low conversion rate from eggs to pupae.
  • Findings suggest that factors like poor larval survival and low mating success are key barriers to effectively colonizing FUTAZ in laboratory settings.
View Article and Find Full Text PDF

Background: In rural south-eastern Tanzania, Anopheles funestus is a major malaria vector, and has been implicated in nearly 90% of all infective bites. Unfortunately, little is known about the natural ecological requirements and survival strategies of this mosquito species.

Methods: Potential mosquito aquatic habitats were systematically searched along 1000 m transects from the centres of six villages in south-eastern Tanzania.

View Article and Find Full Text PDF