Publications by authors named "Emmanuel D'estanque"
Background: Myocardial salvage is an important surrogate endpoint to estimate the impact of treatments in patients with ST-segment elevation myocardial infarction (STEMI).
Aim: The aim of this study was to evaluate the correlation between cardiac sympathetic denervation area assessed by single-photon emission computed tomography (SPECT) using iodine-123-meta-iodobenzylguanidine (I-MIBG) and myocardial area at risk (AAR) assessed by cardiac magnetic resonance (CMR) (gold standard).
Patients And Methods: A total of 35 postprimary reperfusion STEMI patients were enrolled prospectively to undergo SPECT using I-MIBG (evaluates cardiac sympathetic denervation) and thallium-201 (evaluates myocardial necrosis), and to undergo CMR imaging using T2-weighted spin-echo turbo inversion recovery for AAR and postgadolinium T1-weighted phase sensitive inversion recovery for scar assessment.
We report the case of a 73-year-old man with a documented (renal biopsy) light-chain amyloidosis (AL) imaged with F-AV-1 (F-florbetaben) compared with a volunteer. A cardiac amyloidosis was suspected. As it was an AL and not a transthyretin amyloidosis, F-FDG and F-florbetaben PET/CT were preferred to bone scan.
View Article and Find Full Text PDFBackground: Dual-isotope Tl/I-MIBG SPECT can assess trigger zones (dysfunctions in the autonomic nervous system located in areas of viable myocardium) that are substrate for ventricular arrhythmias after STEMI. This study evaluated the necessity of delayed acquisition and scatter correction for dual-isotope Tl/I-MIBG SPECT studies with a CZT camera to identify trigger zones after revascularization in patients with STEMI in routine clinical settings.
Methods: Sixty-nine patients were prospectively enrolled after revascularization to undergo Tl/I-MIBG SPECT using a CZT camera (Discovery NM 530c, GE).
Article Synopsis
- The study compared standard bone SPECT/CT imaging using filtered backprojection (FBP) with an optimized low-dose technique using adaptive statistical iterative reconstruction (ASiR).
- Results showed no significant differences in image quality or performance between FBP and ASiR for both SPECT and CT images, as assessed by visual and quantitative measures.
- Importantly, the ASiR CT protocol achieved a 60% reduction in radiation dose compared to the FBP CT protocol without compromising image quality.