Synopsis of recent research by authors named "Emmanuel C Patin"
- Emmanuel C. Patin's recent research focuses on the intersection of radiotherapy, immune checkpoint inhibitors, and selective targeting of the tumor microenvironment, particularly in models of head and neck squamous cell carcinoma and BRAF-mutant cancers, to enhance anti-tumor immune responses.
- Key findings include the identification of ATR (ataxia telangiectasia and Rad3-related) inhibition combined with radiotherapy as a method to increase the efficacy of T-cell responses, as well as the potential of RIPK1 degradation to promote immunogenic cell death in cancer treatment.
- His studies emphasize the necessity of understanding the immunobiology of cancer therapies and the impact of the inflammatory tumor microenvironment, aiming to develop novel combination therapies that improve patient responses to immunotherapy and radiotherapy.
