Publications by authors named "Emmanuel Boadi Amoafo"
Intra-abdominal sepsis is a life-threatening complex syndrome caused by microbes in the gut microbiota invading the peritoneal cavity. It is one of the major complications of intra-abdominal surgery. To date, only supportive therapies are available.
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- * Cancer cells can outsmart the immune system by creating a tumor microenvironment (TME) that suppresses immune responses, and macrophages in the TME often support tumor growth through their immunosuppressive behavior.
- * There’s potential for targeting the interaction between platelets and macrophages in the TME to reprogram macrophages to fight cancer, suggesting new therapeutic avenues for tumor suppression.
Article Synopsis
- - Sepsis is a severe infection-induced condition marked by a strong inflammatory response involving multiple immune system components, with no current specific treatment available.
- - Blood platelets are primarily known for stopping bleeding but also play a role in inflammation by interacting with other immune cells, showing increased activation in sepsis patients.
- - Antiplatelet therapy, specifically targeting P2Y receptors, shows mixed results in studies, suggesting that blocking these receptors may influence sepsis outcomes, though research challenges remain.
Article Synopsis
- * Research has shown that P2Y is also present in various immune cells, such as monocytes, dendritic cells, and T lymphocytes, leading to investigations on its role in inflammatory conditions like sepsis, cancer, and COVID-19.
- * The review discusses P2Y's expression in the immune system, its impact on inflammation, and the challenges faced in researching this receptor, along with potential solutions to these issues.
Article Synopsis
- - Sepsis is a serious infection that leads to high mortality and shows differences in immune responses based on sex, but the exact mechanisms behind this are still unclear.
- - Research indicates that blocking the P2Y ADP-receptor has protective effects during sepsis in males but not in females, suggesting sex-related differences in how these pathways function.
- - Experiments with male and female mice showed significant reductions in sepsis-related platelet activation and immune responses when P2Y was blocked, but this effect was not observed in female mice, highlighting distinct immune characteristics based on sex.