Publications by authors named "Emmanouil Angelos Rigopoulos"

Article Synopsis
  • Amphotericin B (AmB) is a key treatment for invasive fungal infections (IFIs), especially in immunocompromised patients, but new antifungal options are emerging.
  • The rise of these alternatives is due to increased IFI occurrences, changing fungal resistance patterns, and a growing number of immunocompromised individuals, driving the demand for effective treatments.
  • Even with new agents, AmB remains valuable due to its effectiveness, low resistance rates, and improved formulations that reduce side effects, ensuring its continued relevance in clinical practice.
View Article and Find Full Text PDF

Primary Epstein-Barr virus (EBV) infection manifests with diverse clinical symptoms, occasionally resulting in severe complications. This scoping review investigates the rare occurrence of acute acalculous cholecystitis (AAC) in the context of primary EBV infection, with a focus on understanding its prevalence, clinical features, and underlying mechanisms. The study also explores EBV infection association with Gilbert syndrome, a condition that potentially exacerbates the clinical picture.

View Article and Find Full Text PDF

In the years of Coronavirus Disease 2019 (COVID-19), various treatment options have been utilized. COVID-19 continues to circulate in the global population, and the evolution of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has posed significant challenges to the treatment and prevention of infection. Remdesivir (RDV), an anti-viral agent with in vitro efficacy against coronaviruses, is a potent and safe treatment as suggested by a plethora of in vitro and in vivo studies and clinical trials.

View Article and Find Full Text PDF

The clinical management of COVID-19 in pregnant women, who are considered a vulnerable population, remains uncertain even as the pandemic subsides. SARS-CoV-2 affects pregnant individuals in multiple ways and has been associated with severe maternal morbidity and mortality, as well as neonatal complications. The unique anatomy and physiology of gestation make managing COVID-19 in this population a complex and challenging task, emphasizing the importance of spreading knowledge and expertise in this area.

View Article and Find Full Text PDF

Effective treatments and vaccines against COVID-19 used in clinical practice have made a positive impact on controlling the spread of the pandemic, where they are available. Nevertheless, even if fully vaccinated, immunocompromised patients still remain at high risk of adverse outcomes. This has driven the largely expanding field of monoclonal antibodies, with variable results.

View Article and Find Full Text PDF