Stated preferences for relapsed or refractory mantle cell lymphoma treatments in Sweden and Germany.

We aimed to elicit treatment preferences in relapsed/refractory mantle cell lymphoma (r/r MCL). A discrete-choice experiment comprising six attributes ('overall survival', 'progression-free survival', 'fatigue', 'nausea', 'risk of serious infections' and 'treatment administration') was administered to r/r MCL patients, physicians and the general population (GP) in Sweden and Germany. 18 patients, 68 physicians and 191 GP members participated.

Metered-dose inhaler ipratropium bromide in moderate acute asthma in children: A single-blinded randomised controlled trial.

Aim: To determine if the addition of ipratropium bromide (IB) by metered-dose inhaler in moderate acute asthma in children affects hospital admission rates when compared with inhaled salbutamol and oral prednisolone alone.

Methods: A prospective, single-blinded, randomised, controlled, equivalence trial in a tertiary paediatric emergency department. Patients aged 2-15 years with acute, moderate asthma were randomised to two groups, one receiving salbutamol, prednisolone and IB, the other receiving only salbutamol and prednisolone.

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase.

Enriching chemical space with diversity-oriented synthesis.

The search for new molecular entities in drug discovery and chemical genetic programs requires the screening of high-quality collections of structurally diverse small molecules. The design and synthesis of such collections remains a major challenge to synthetic chemists. Recent strategies and results are presented in the context of the chemical space being interrogated.

Skeletal diversity construction via a branching synthetic strategy.

A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was demonstrated.