Publications by authors named "Emma W Rosenblum"
The hippocampus is heterogeneous in its architecture. It contributes to cognitive processes such as memory and spatial navigation and is susceptible to neurodegenerative disease. Cytoarchitectural features such as neuron size and neuronal collinearity have been used to parcellate the hippocampal subregions.
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- The prosubiculum (ProS) is a distinct neuroanatomical region in the hippocampus, found in mice, monkeys, and humans, lying between CA1 and subiculum (Sub).
- Researchers identified four unique cytoarchitectural features that differentiate ProS from adjacent subfields: small neurons, lightly stained neurons, superficial clustered neurons, and a zone with fewer cells.
- The study quantitatively measured the size of ProS pyramidal neurons, finding them to be smaller than those in CA1 and Sub, indicating that ProS may serve specific functional roles within the hippocampal network and highlighting its complex structure.
Article Synopsis
- Hippocampal subregions show differences in how they handle neuron loss and cell death, which is significant in the progression of Alzheimer's disease.
- Researchers developed a deep learning pipeline using the CellPose algorithm to accurately segment hippocampal pyramidal neurons and validate these results against traditional stereological methods.
- The study found strong correlations between deep learning estimates and manual neuron counts, indicating this automated approach could be useful for future research on aging and disease progression.
Introduction: The hippocampus is integral for learning and memory and is targeted by multiple diseases. Neuroimaging approaches frequently use hippocampal subfield volumes as a standard measure of neurodegeneration, thus making them an essential biomarker to study. Collectively, histologic parcellation studies contain various disagreements, discrepancies, and omissions.
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