Publications by authors named "Emma Sanborn"
Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological condition that classically presents with recurrent, thunderclap headaches and radiographic findings of multifocal narrowing of cerebral vasculature. Complications of RCVS may include ischemic or hemorrhagic strokes. Sympathomimetic agents including cannabinoids have been associated as precipitants in many cases.
View Article and Find Full Text PDFDiffuse cortical diffusion changes on magnetic resonance imaging (MRI) are characteristically ascribed to global cerebral anoxia, typically after cardiac arrest. Far from being pathognomonic, however, this neuroimaging finding is relatively nonspecific, and can manifest in a myriad of disease states including hypoxia, metabolic derangements, infections, seizure, toxic exposures, and neuroinflammation. While these various conditions can all produce a neuroimaging pattern of widespread cortical diffusion restriction, many of these underlying causes do have subtly unique imaging features that are appreciable on MRI and can be of clinical and diagnostic utility.
View Article and Find Full Text PDFAcute ischaemic stroke associated with SARS-CoV-2 infection in North America.
J Neurol Neurosurg Psychiatry
April 2022
Background: To analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.
Methods: Multicentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at discharge.
Article Synopsis
- - Nilotinib, a medication used to treat chronic myelogenous leukemia (CML), may lead to serious vascular problems like accelerated arterial stenosis, particularly atherosclerosis, which can result in conditions such as acute stroke, even in patients with no prior cardiovascular risk factors.
- - The exact reasons why nilotinib triggers atherosclerosis are not well understood, but potential factors include issues with blood vessel linings, metabolism, and changes in fat and glucose levels.
- - Healthcare providers should be vigilant about the possible risk of vascular diseases associated with nilotinib and consider screening for cardiovascular issues in patients before starting treatment, as well as monitoring them closely throughout the therapy.
Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients.
Aim: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease.
Methods: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020-16 June 2020).