Publications by authors named "Emma Redgate"
Article Synopsis
- Elf5 is a key transcription factor for proper trophoblast development in mice, as its knockdown leads to increased differentiation of stem cells without affecting proliferation or cell death.
- Following Elf5 knockdown, the stem cells quickly lose expression of critical pluripotency genes (Sox2 and Sox3) and temporarily express Hand1, a gene linked to giant cell differentiation.
- The study indicates that Elf5 acts as a regulatory gatekeeper, preventing premature differentiation of extraembryonic ectoderm into trophoblasts, highlighting its essential role in maintaining stem cell properties during early development.
