Publications by authors named "Emma R Kelly"
Article Synopsis
- DNA damage response mechanisms are crucial for successful gamete formation during meiosis, ensuring proper repair of double-strand breaks (DSBs).
- The study highlights that while RAD9A-RAD1-HUS1 (the canonical 9-1-1 complex) is important for DSB repair, mammalian meiocytes also use RAD9B and HUS1B as alternative components that can form different 9-1-1 complexes.
- Disruption of the RAD1 subunit in mice led to severe infertility issues, including poor DSB repair, depletion of germ cells, and defects in key meiotic processes such as homolog synapsis and sex chromosome inactivation.
Background: Exposure to toxic metals (TMs) such as lead can cause lifelong neurodevelopmental impairment and other adverse outcomes. TMs enter drinking water from human activity, geogenic contamination, and corrosion of water system components. Several studies report TM contamination in piped systems and private wells in high-income countries (HICs).
View Article and Find Full Text PDFSanitary inspection is used in low-, medium- and high-income settings to assess the risk of microbial contamination at water sources. However, the relationship between sanitary inspection and water quality is not well understood. We conducted a critical literature review and synthesized the findings of 25 studies comparing the results of sanitary inspection and microbial water quality analysis.
View Article and Find Full Text PDFObjectives: Effective regionalization of acute stroke care requires assessment and coordination of limited hospital resources. We described the availability of stroke-specific hospital resources (neurology specialty physicians and neuro-intensive care unit [neuro-ICU] bed capacity) for North Carolina overall and by region and population density. We also assessed daily trends in hospital bed availability.
View Article and Find Full Text PDFAchieving sufficient, safe, continuously-available drinking water services in rural areas is a challenge, in high- and especially low-and middle-income countries. External support programs (ESPs) - which may include administrative, financial, and technical assistance - have been hypothesized to contribute to sustainable rural water services. While there are many descriptions of ESPs, a standard terminology and typology of ESP activities does not exist and the effect of ESP activities on system sustainability remains inadequately characterized.
View Article and Find Full Text PDFBackground: Packaged water products provide an increasingly important source of water for consumption. However, recent studies raise concerns over their safety.
Objectives: To assess the microbial safety of packaged water, examine differences between regions, country incomes, packaged water types, and compare packaged water with other water sources.