Publications by authors named "Emma P Strainis"
Article Synopsis
- - The study investigates isolated REM sleep behavior disorder (iRBD) and its links to neurodegenerative diseases, focusing on gender differences and younger adults, which are less explored compared to older males.
- - Researchers followed 372 participants (186 women and 186 men with iRBD), finding that women were diagnosed at a younger age than men and that over 12% converted to a neurodegenerative disorder within roughly 6 years.
- - Key findings indicate that older age at diagnosis is a significant factor for phenoconversion risk, with lower risk observed in those using antidepressants or having chronic pain, while higher risk was noted in individuals with vascular issues.
Study Objectives: Accurate diagnosis of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is crucial due to its injury potential and neurological prognosis. We aimed to analyze visual and automated REM sleep without atonia (RSWA) diagnostic thresholds applicable in varying clinical presentations in a contemporary cohort of patients with iRBD using submentalis (SM) and individual bilateral flexor digitorum superficialis (FDS) and anterior tibialis electromyography limb recordings during polysomnography.
Methods: We analyzed RSWA in 20 patients with iRBD and 20 age-, REM-, apnea-hypopnea index-matched controls between 2017 and 2022 for phasic burst durations, density of phasic, tonic, and "any" muscle activity (number of 3-second mini-epochs containing phasic or tonic muscle activity divided by the total number of REM sleep 3-second mini-epochs), and automated Ferri REM atonia index (RAI).