Publications by authors named "Emma M Pearce"
Hematopoietic cell transplantation (HCT) uses cytotoxic chemotherapy and/or radiation followed by intravenous infusion of stem cells to cure malignancies, bone marrow failure and inborn errors of immunity, hemoglobin and metabolism. Lung injury is a known complication of the process, due in part to disruption in the pulmonary microenvironment by insults such as infection, alloreactive inflammation and cellular toxicity. How microorganisms, immunity and the respiratory epithelium interact to contribute to lung injury is uncertain, limiting the development of prevention and treatment strategies.
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- Lung injury is really important for kids' survival after getting special treatments for blood diseases, and scientists want to learn more about how germs and the body work together in the lungs.
- In a big study, researchers looked at lung samples from 229 kids at 32 hospitals over 8 years and found 4 different groups of patients based on their lung microbe makeup.
- Each group had different health outcomes: one group had low infection rates and low death rates, while others had high infection and death rates, showing that the type of lung microbes can greatly affect survival.
is a genus of Gram-positive bacteria with species that can cause growth deformations to a large number of plant species. This ability to cause disease is hypothesized to be dependent on a cluster of three gene loci on an almost 200 kb-sized linear plasmid. To reevaluate the roles of some of the genes in pathogenicity, we constructed and characterized deletion mutants of and four genes.
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