Publications by authors named "Emma Karlsen"
Article Synopsis
- Keratinocyte carcinomas, like basal and squamous cell carcinomas, are common and serious issues for solid organ transplant recipients, necessitating early detection and effective treatment strategies.
- A Phase III clinical trial, called the SiroSkin trial, will assess the effectiveness of topical sirolimus in reducing skin cancer incidence among these patients compared to a placebo, involving 146 participants over 24 weeks of treatment and 18 months of follow-up.
- The trial's results aim to enhance management approaches for skin cancers in solid organ transplant recipients and gather evidence on the cost-effectiveness of using topical sirolimus.
Background: Elevated blood eosinophil counts are linked to worse outcomes in asthma and COPD, but have yet to be well characterized in CF. We hypothesized that higher stable visit blood eosinophil counts are associated with increased rates of lung function decline and pulmonary exacerbations (PEx).
Methods: We performed a retrospective analysis of adult CF patients (≥19 years) enrolled from 2012 to 2018 in a prospective cohort study focused on blood biomarkers.
Article Synopsis
- Cystic fibrosis (CF) affects various organs, including the pancreas, which can lead to cystic fibrosis-related diabetes (CFRD), impacting survival rates if untreated.
- Researchers built a CFRD prediction model using genetic data from a Canadian study and validated it with data from a French study, highlighting key predictors like sex and certain genetic variants.
- The final model successfully identifies individuals at high risk for CFRD and has led to the creation of a web-based tool that helps doctors monitor and treat patients based on their specific risk levels.