Publications by authors named "Emma J Sandago"
Article Synopsis
- Opioid use during pregnancy can cause serious health issues for infants, like neonatal opioid withdrawal syndrome (NOWS), which involves various dysfunctions that require tailored treatment approaches.* -
- A study on neonatal mice revealed increased ultrasonic vocalizations (USVs) during opioid withdrawal, with significant behavioral and mRNA changes associated with kappa opioid receptors implicated in stress responses.* -
- Findings suggest that the kappa opioid receptor plays a critical role in withdrawal-related distress, particularly in female mice, highlighting variations in USV patterns and responses in males and females during this process.*
Rationale: Opioid use during pregnancy can lead to negative infant health outcomes, including neonatal opioid withdrawal syndrome (NOWS). NOWS comprises gastrointestinal, autonomic nervous system, and neurological dysfunction that manifest during spontaneous withdrawal. Variability in NOWS severity necessitates a more individualized treatment approach.
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