Acids produced by lactobacilli inhibit the growth of commensal and S24-7 bacteria.

The are an intensively studied family of bacteria widely used in fermented food and probiotics, and many are native to the gut and vaginal microbiota of humans and other animals. Various studies have shown that specific species produce metabolites that can inhibit the colonization of fungal and bacterial pathogens, but less is known about how affect individual bacterial species in the endogenous animal microbiota. Here, we show that numerous species inhibit the growth of the family and the S24-7 group, two dominant clades of bacteria within the gut.

The CIAMIB: a Large and Metabolically Diverse Collection of Inflammation-Associated Bacteria from the Murine Gut.

Gut inflammation directly impacts the growth and stability of commensal gut microbes and can lead to long-lasting changes in microbiota composition that can prolong or exacerbate disease states. While mouse models are used extensively to investigate the interplay between microbes and the inflamed state, the paucity of cultured mouse gut microbes has hindered efforts to determine causal relationships. To address this issue, we are assembling the Collection of Inflammation-Associated Mouse Intestinal Bacteria (CIAMIB).