Publications by authors named "Emma Hampson"
Article Synopsis
- The study explores the use of targeted nanoparticles (RGD-ELNP) carrying miR-200c to modify the extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) and inhibit tumor growth.
- In mouse models, the treatment significantly reduced ECM proteins associated with tumor progression and inhibited the ability of PDAC cells to form structures and migrate.
- Non-invasive imaging techniques (MT218-MRMI) effectively tracked changes in tumor ECM and confirmed the therapeutic efficacy of RGD-ELNP/miR-200c, showing promise for improving PDAC treatment strategies.
Importance: The US arrival of the Omicron variant led to a rapid increase in SARS-CoV-2 infections. While numerous studies report characteristics of Omicron infections among vaccinated individuals or persons with previous infection, comprehensive data describing infections among adults who are immunologically naive are lacking.
Objectives: To examine COVID-19 acute and postacute clinical outcomes among a well-characterized cohort of unvaccinated and previously uninfected adults who contracted SARS-CoV-2 during the Omicron (BA.
Importance: The U.S. arrival of the Omicron variant led to a rapid increase in SARS-CoV-2 infections.
View Article and Find Full Text PDFObjectives: To measure the rate of benzodiazepine receptor agonist (BZA) dependence in older veterans with insomnia symptoms chronically using BZAs and to assess for associations between high posttraumatic stress disorder (PTSD) risk and BZA dependence.
Methods: A cross-sectional study was conducted among veterans aged 55 years and older with insomnia symptoms (current or historical) and chronic use of BZAs (≥3 months). Measurements included the Primary Care-PTSD screen (score >2 indicates high PTSD risk) and Benzodiazepine Dependence Questionnaire.
Exposure to stressors can enhance neuroinflammatory responses, and both stress and neuroinflammation are predisposing factors in the development of psychiatric disorders. Females suffer disproportionately more from several psychiatric disorders, yet stress-induced changes in neuroinflammation have primarily been studied in males. Here we tested whether exposure to inescapable tail shock sensitizes or 'primes' neuroinflammatory responses in male and female rats.
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