Publications by authors named "Emma Elphick"
Background: Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically important outcome to be reported in all trials. However, there is wide variation in how peritoneal dialysis technique survival is defined, measured and reported, leading to difficulty in comparing or consolidating results.
Methods: We conducted an online international consensus workshop to establish a core outcome measure of technique survival.
Article Synopsis
- The study examines how technique survival in peritoneal dialysis (PD) is defined and measured across various randomized controlled trials (RCTs), highlighting inconsistencies in terminology and definitions.
- A total of 25 RCTs with 3,645 participants were reviewed, revealing 17 different definitions of technique survival, with many studies lacking clarity on whether transfers to hemodialysis or patient deaths were included in their definitions.
- The findings indicate significant variability in the reporting of technique survival, suggesting a need for standardized definitions to enhance comparability in future PD research.
Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport.
Clin J Am Soc Nephrol
October 2018
Background And Objectives: The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because biocompatible solutions were developed to mitigate these effects, we examined the association with their use and longitudinal peritoneal solute transport rate.
Design, Setting, Participants, & Measurements: We analyzed subjects from the multinational prospective Global Fluid Study with three or more peritoneal solute transport rate measurements >2 months from the start of peritoneal dialysis.
Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in which comorbidity and overhydration, quantified by whole body bioimpedance (BI), were reported. PubMed, EMBASE, PsychInfo and the Cochrane trial database were searched (1990-2017).
View Article and Find Full Text PDF