Publications by authors named "Emma E Oldridge"
The origin and phenotype of stem cells in human prostate cancer remains a subject of much conjecture. In this scenario, CD133 has been successfully used as a stem cell marker in both normal prostate and prostate cancer. However, cancer stem cells have been identified without the use of this marker, opening up the possibility of a CD133 negative cancer stem cell.
View Article and Find Full Text PDFThe prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-responsive, but androgen-independent, basal compartment in which stem cells reside.
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- Epigenetic control is vital for maintaining tissue structure and differentiation, but in cancer, this control is disrupted, affecting markers like CD133, which is linked to adult stem cells.
- The study analyzed CD133's regulation through methods like DNA methylation analysis and gene expression measurement, finding that CD133 expression is often repressed by heavy DNA methylation in prostate epithelial cell lines.
- Results showed that while DNA methylation patterns differ in cancerous samples, treatment with HDAC inhibitors can restore CD133 expression, indicating its regulation is complex and tied to chromatin structure.