Trying to do my best as a mother: decision-making in families of children undergoing elective surgical treatment for short stature.

Objectives: To explore how families make decisions about elective leg-lengthening surgical treatment.

Design: Interviews were conducted and analysed using Interpretative Phenomeno logical Analysis (Smith, 1995).

Methods: Data were gathered using semi-structured interviews with nine mothers of children who had recently decided to undergo treatment.

Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?

Dopamine and endogenous cannabinoids display complex interactions in the basal ganglia. One possible level of interaction is between CB1 cannabinoid and D2 dopamine receptors. Here, we demonstrate that a regulated association of CB1 and D2 receptors profoundly alters CB1 signaling.

Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease.

Genome sequencing projects have focused attention on the problem of discovering the functions of protein domains that are widely distributed throughout living species but which are, as yet, largely uncharacterized. One such example is the PIN domain, found in eukaryotes, bacteria, and Archaea, and with suggested roles in signaling, RNase editing, and/or nucleotide binding. The first reported crystal structure of a PIN domain (open reading frame PAE2754, derived from the crenarchaeon, Pyrobaculum aerophilum) has been determined to 2.