Publications by authors named "Emma Chang-Rabley"
The SARS-CoV-2 pandemic has heightened concerns about immunological protection, especially for individuals with inborn errors of immunity (IEI). While COVID-19 vaccines elicit strong immune responses in healthy individuals, their effectiveness in IEI patients remains unclear, particularly against new viral variants and vaccine formulations. This uncertainty has led to anxiety, prolonged self-isolation, and repeated vaccinations with uncertain benefits among IEI patients.
View Article and Find Full Text PDFBackground: People who are immune-deficient/disordered (IDP) are underrepresented in COVID-19 studies. Specifically, there is limited research on post-SARS-CoV-2 infection outcomes, including viral persistence and long-term sequelae in these populations.
Objectives: This review aimed to examine the published literature on the occurrence of persistent SARS-CoV-2 positivity, relapse, reinfections, variant coinfection, and post-acute sequelae of COVID-19 in IDP.
Article Synopsis
- Research on COVID-19 vaccination in immune-deficient people largely centers on cancer and organ transplant recipients, showing that 88% developed antispike IgG after the second vaccine dose, increasing to 93% by six months post-third dose.
- However, the antibody levels in immune-deficient patients were significantly lower than those in healthy volunteers, never exceeding one-third of their levels.
- The study suggests that while three doses of the vaccine generate an antibody response, additional doses may be necessary for improved protection, especially against the Omicron BA.1 variant, warranting further investigation into the effectiveness of booster shots.