Publications by authors named "Emma Ce Wassenaar"
Article Synopsis
- The study investigates whether primary tumor cells can metastasize randomly or require specialized traits by examining 26 colorectal cancer patients with peritoneal metastases.
- Using a detailed sampling method, the research finds that peritoneal metastases are more heterogeneous than liver metastases and influenced by factors like chemotherapy.
- The origins of peritoneal metastases are often at the deep-invading edge of primary tumors and generally do not share a common subclonal origin with distant metastases, indicating different selective pressures impacting cancer cells during metastasis.
Article Synopsis
- Tumor-derived cell-free DNA (cfDNA) shows promise as a biomarker for personalizing treatment in metastatic colorectal cancer (CRC), but its effectiveness varies depending on the type of metastasis.
- A study analyzed cfDNA in plasma and peritoneal fluid from CRC patients, revealing that while high cfDNA levels are common in CRC liver metastases (CRC-LM), they are significantly lower in plasma of CRC patients with peritoneal metastases (CRC-PM).
- Findings suggest that detecting cfDNA in peritoneal fluid is more reliable for monitoring CRC-PM, offering a potential alternative for guiding treatment decisions compared to plasma analysis.
Introduction: Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy with oxaliplatin (ePIPAC-OX) is offered as a palliative treatment option for patients with isolated unresectable colorectal peritoneal metastases (PM) in several centres worldwide. However, little is known about its feasibility, safety, tolerability, efficacy, costs and pharmacokinetics in this setting. This study aims to explore these parameters in patients with isolated unresectable colorectal PM who receive repetitive ePIPAC-OX as a palliative monotherapy.
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