Publications by authors named "Emma Bednarski"
Cell Chem Biol
January 2020
Article Synopsis
- Deregulation of the PRC2 complex, which is important for gene regulation, leads to abnormal cancer growth due to hypermethylation of histone H3K27.
- Despite promising results from EZH2 inhibitors, resistance can develop from mutations in EZH2 that escape drug effects.
- The newly designed PROTACs target EED for degradation, effectively inhibiting PRC2 activity and reducing the growth of cancer cells dependent on PRC2, showcasing a novel therapeutic approach.
