Acute Effects of Nicotine on Non-Drug-Related Reward in Smokers and Non-Smokers.

Introduction: Nicotine increases the reward value of non-drug-related stimuli in animals and dependent smokers; however, research on people who are not dependent on nicotine is limited. This study aimed to explore whether nicotine delivered by oral spray can enhance responding to self-selected sensory rewards in both smokers and non-smokers.

Aims And Methods: Minimally abstinent smokers (n = 30) and non-smokers (n = 31) completed subjective ratings of nicotine withdrawal, and received either 2 mg nicotine or placebo oral spray and visual analogue scales to measure the perceived effects of the spray.