[Tc]Technetium-Labeled Niosomes: Radiolabeling, Quality Control, and Evaluation.

The aim of this research was to develop technetium-99m ([Tc]Tc)-radiolabeled niosomes and evaluate the cancer cell incorporation capacity of radiolabeled niosomes. For this purpose, niosome formulations were developed by film hydration method, and prepared niosomes were characterized to particle size, polydispersity index (PdI), ζ-potential value, and image profile. Then, niosomes were radiolabeled with [Tc]Tc using stannous salts (chloride) as a reducing agent.