Publications by authors named "Emine Cesmecioglu"
Article Synopsis
- AI technology in pathology relies on supervised machine learning and is increasingly used for tasks like detecting invasive breast cancer and analyzing tissue layers in colorectal specimens.
- The study involved training convolutional neural networks (CNNs) using a large dataset of whole-slide images (WSIs) across different cancer types, achieving notable F1 scores for diagnostic accuracy.
- After extensive training and external validation, the AI models demonstrated a high level of proficiency in identifying tumors and distinguishing between various tissue layers.
Article Synopsis
- Gene amplification and protein overexpression of HER2 are significant markers for prognosis and treatment in invasive breast carcinoma (IBC), with accurate IHC scoring (0 to 3+) being crucial for appropriate patient classification.
- ASCO/CAP recommends HER2 assessment through immunohistochemistry (IHC) and hybridization (ISH) tests, highlighting the importance of differentiating between HER2 IHC scores (especially 0, 1+, and 2+/ISH-) to optimize targeted therapies.
- A study analyzed 32 calibration and 77 validation datasets using software for HER2 IHC scoring, demonstrating high concordance and sensitivity between manual and semi-automated methods, yet noting challenges like staining artifacts that could affect accuracy.
In colorectal carcinoma (CRC), tumor deposits (TDs) are described as macroscopic/microscopic nests/nodules in the lymph drainage area discontinuous with the primary mass, without identifiable lymph node (LN) tissue, and not confined to vascular or perineural spaces. A TD is categorized as pN1C only when no bona fide LN metastasis exists. However, there has been an ongoing debate on whether TDs should be counted as LNs.
View Article and Find Full Text PDFPrimary bone lipogranuloma is an extremely rare disease associated with reactive inflammatory granulomatous reaction associated with exogenous or endogenous lipids. Herein, we report a case of bone lipogranuloma with intense 18F-FDG uptake, which mimics metastatic disease on 18F-FDG PET/CT in a patient with breast cancer.
View Article and Find Full Text PDFEndoscopic submucosal dissection can remove large superficial gastrointestinal lesions in en bloc. A detailed pathological evaluation of the resected specimen is required to assess the risk of recurrence after treatment. However, the current method of sectioning specimens to a thickness of a few millimeters does not provide information between the sections that are lost during the preparation.
View Article and Find Full Text PDFWhole-block imaging (WBI) using micro-computed tomography (micro-CT) allows the nondestructive reconstruction of a three-dimensional view of tissues, implying that WBI may be used for accurate pathological evaluation of patients with rectal cancer. HOWEVER, the clinical impact of this approach is unclear. We aimed to clarify the efficacy of WBI in the whole-mount specimens of locally advanced rectal cancer.
View Article and Find Full Text PDFObjectives: Fibrosing cholestatic hepatitis is an aggressive and usually fatal form of viral hepatitis in immunosuppressed patients. We assessed the hepatotoxicity of methotrexate and prednisolone combination therapy in the background of hepatitis B virus infection.
Materials And Methods: We report the clinical course of a 55-year-old woman who underwent a deceased-donor liver transplant for fulminant liver failure.