Assessment of temperature-sensitive properties of ionically crosslinked sodium alginate/hydroxypropyl cellulose blend microspheres: preparation, characterization, and in vitro release of paracetamol.

Today, polymer systems can be formed to respond to single stimuli or multiple stimuli by changing their properties. The use of these systems, which are designed to be sensitive to stimuli, is expanding in a wide range of applications. Herein, microspheres of sodium alginate (NaAlg) and hydroxypropyl cellulose (HPC) sensitive to dual stimuli for the controlled release of model drug paracetamol were produced by the ionotropic gelation method in the presence of Zn ions.

Synergistic effect of ZnO nanoparticles and hesperidin on the antibacterial properties of chitosan.

In this study, hesperidin (HSP) biological agent, which has strong antioxidant properties, was successfully transferred to ZnO nanoparticles, which were first synthesized by the hydrothermal method. Then, chitosan (CS)/ZnO-HSP nanocomposites were produced by adding different ratios of the ZnO-HSPs to the biodegradable CS biopolymer by hydrothermal method. The resulting materials were characterized using various biophysical strategies, including X-ray diffraction (XRD), Fourier transform infrared spectrometry, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy.

Synthesis and characterization of temperature-sensitive microspheres based on acrylamide grafted hydroxypropyl cellulose and chitosan for the controlled release of amoxicillin trihydrate.

This study deals with the preparation of temperature-sensitive chitosan/hydroxypropyl cellulose-graft-polyacrylamide (CS/HPC-g-PAAm) blend microspheres as a controlled drug release system. For this purpose, HPC-g-PAAm copolymers of hydroxypropyl cellulose (HPC) with acrylamide (AAm) were synthesized using cerium (IV) ammonium nitrate as initiator. The HPC-g-PAAm copolymers were characterized by using Fourier transform infrared spectroscopy (FTIR), elemental analysis, and differential scanning calorimetry (DSC).

Development and optimization of Fe-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.

In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.

Flurbiprofen-loaded interpenetrating polymer network beads based on alginate, polyvinyl alcohol and methylcellulose: design, characterization and in-vitro evaluation.

The main objective of this study was to develop an appropriate interpenetrating polymer network (IPN) particulate system from water-soluble polymers such as sodium alginate (NaAlg), poly (vinyl alcohol) (PVA) and methyl cellulose (MC) for the controlled release of flurbiprofen (FBP), a non-steroidal anti-inflammatory drug. Therefore, polymeric IPN beads containing FBP were prepared by crosslinking with glutaraldehyde (GA) as the crosslinking agent and by varying experimental variables such as polymer ratio, crosslinking time and drug/polymer ratio. Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were used to characterize the IPN beads.

Controlled delivery of the popular nonsteroidal anti-inflammatory drug, paracetamol, from chitosan-g-polyacrylamide microspheres prepared by the emulsion crosslinking technique.

In this paper, chitosan-graft-polyacrylamide (CS-g-PAAm) microspheres as drug delivery matrices of paracetamol were prepared by the emulsion crosslinking technique, using glutaraldehyde (GA) as a crosslinker. Graft copolymer of chitosan with acrylamide was synthesized using cerium (IV) ammonium nitrate (CAN). The microspheres formed had average particle sizes in the range of 78-252 μm.

Ibuprofen microencapsulation within acrylamide-grafted chitosan and methylcellulose interpenetrating polymer network microspheres: Synthesis, characterization, and release studies.

This study deals with the development of interpenetrating polymer network (IPN) microspheres of acrylamide (AAm) grafted onto a chitosan (CS) backbone and methylcellulose (MC). Chitosan-graft-polyacrylamide (CS-g-PAAm) was synthesized by cerium (IV) ammonium nitrate-induced free radical graft polymerization. The grafting percentage was found to be 50.

Novel ionically crosslinked acrylamide-grafted poly(vinyl alcohol)/sodium alginate/sodium carboxymethyl cellulose pH-sensitive microspheres for delivery of Alzheimer's drug donepezil hydrochloride: Preparation and optimization of release conditions.

In this work, the graft copolymer, poly(vinyl alcohol)-grafted polyacrylamide (PVA-g-PAAm), was synthesized and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and elemental analysis. Microspheres of PVA-g-PAAm/sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) were prepared by the emulsion-crosslinking method and used for the delivery of an Alzheimer's drug, donepezil hydrochloride (DP). The release of DP increased with the increase in drug/polymer ratio (d/p) and PVA-g-PAAm/NaAlg/NaCMC ratio, while it decreased with the increase in the extent of crosslinking.