Aim: In this study, we investigated the effects of necrostatin-1 (NEC-1) on subarachnoid hemorrhage (SAH)-induced vasospasm in a rat model.
Material And Methods: 59 male Wistar albino rats were randomly divided into six groups: control (group 1), sham (group 2), decapitation one hour after SAH (group 3), decapitation 48 hours after SAH (group 4), NEC-1 given 15 minutes before SAH and decapitation one hour after SAH (group 5), and NEC-1 given 24 hours after SAH and decapitation 48 hours after SAH (group 6). NEC-1 (1 uq) was administered intracisternally in dimethyl sulfoxide (DMSO) (2.