Publications by authors named "Emily Y Qian"
Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88.
Am J Physiol Lung Cell Mol Physiol
January 2024
Article Synopsis
- Cell-free hemoglobin (CFH) in the lungs of patients with acute respiratory distress syndrome (ARDS) causes inflammation and lung injury, but the mechanisms are not fully understood.
- Researchers hypothesized that Toll-like receptor 4 (TLR4) plays a role in mediating the inflammatory response to CFH.
- Their findings showed that mice lacking TLR4 had less inflammation and lung permeability, indicating that TLR4 signaling activates key inflammatory pathways after CFH exposure.