Publications by authors named "Emily X Johns"
Article Synopsis
- Bispecific T cell engagers (BiTEs) are antibodies designed to redirect T cells towards tumors that express specific antigens, showing potential as a therapy for solid tumors like glioblastomas.
- The study focused on certain tumor-associated antigens (EGFR and IL13Rα2) found in glioma tissues and developed multivalent BiTEs to improve targeting and treatment efficacy.
- BiTE-secreting T cells showed better activation and anti-tumor responses compared to CAR T cells, particularly in early phases of treatment in a glioma mouse model, highlighting their strong therapeutic potential for solid tumors.
