Publications by authors named "Emily Wagstrom"
Objectives: We conducted a large, U.S wide, observational study of type III tibial fractures, with the hypothesis that delays between definitive fixation and flap coverage might be a substantial modifiable risk factor associated with nosocomial wound infection.
Design: A retrospective analysis of a multicenter database of open tibial fractures requiring flap coverage.
Article Synopsis
- Despite the common use of antibiotics, surgical site infections remain prevalent in patients with fractures, prompting the need to explore better prevention methods.
- An open-label randomized clinical trial tested the impact of intrawound vancomycin powder on reducing deep surgical site infections in high-risk patients undergoing tibial plateau or pilon fracture surgeries across multiple US trauma centers.
- Results showed that the treatment group had a lower incidence of deep infections (6.4%) compared to the control group (9.8%), with the vancomycin specifically showing a significant effect on gram-positive infections, indicating its potential as an effective intervention in surgical settings.
Introduction: The purpose of our study was to evaluate the factors that influence the timing of definitive fixation in the management of bilateral femoral shaft fractures and the outcomes for patients with these injuries.
Methods: Patients with bilateral femur fractures treated between 1998 to 2019 at ten level-1 trauma centers were retrospectively reviewed. Patients were grouped into early or delayed fixation, which was defined as definitive fixation of both femurs within or greater than 24 hours from injury, respectively.
Article Synopsis
- The study analyzed complications in patients with bilateral femur fractures treated with intramedullary nailing (IMN) in either a single or two-stage procedure across 10 trauma centers from 1998 to 2018.
- A total of 246 patients were assessed, revealing that the single-stage procedure had a significantly lower incidence of acute respiratory distress syndrome (ARDS) compared to the two-stage procedure, although in-hospital mortality was slightly higher in the single-stage group without statistical significance.
- The findings suggest that single-stage IMN may reduce ARDS risk in polytrauma patients, indicating a need for future studies to further explore mortality impacts and identify at-risk individuals.
Objectives: To identify potential physiologic markers of muscle ischemia to serve as diagnostic indicators of compartment syndrome. We hypothesize that muscle bundles in hypoxic conditions will elicit decreases in potential hydrogen (pH) and increases in lactate and potassium that correlates with decreased muscle twitch forces.
Methods: We performed an ex vivo evaluation of individual skeletal muscle bundles obtained from a swine's diaphragm that were exposed to hypoxic conditions and compared with control groups.
Background: Glenohumeral instability is common in athletes. There are an estimated 0.12 episodes of instability per 1000 sporting exposures.
View Article and Find Full Text PDFHypothesis: The purpose of this multicenter epidemiologic study was to determine the distribution of patients within the Frequency, Etiology, Direction, and Severity (FEDS) classification system to determine which categories are of clinical importance.
Methods: Shoulder instability patients were identified using International Classification of Diseases, Ninth Revision coding data from 3 separate institutions from 2005-2010. Data were collected retrospectively.
Purpose Of Review: To review literature published in the last 3 years related to minimally invasive approaches to calcaneal fracture fixation.
Recent Findings: Numerous randomized control trials, cohort studies, and meta-analyses have been done in the last 3 years comparing surgical treatment of calcaneus fractures. These studies indicate minimally invasive procedures decrease wound complication rates and achieve similar radiographic and clinical outcomes to open reduction internal fixation.
Article Synopsis
- Shoulder instability is common among young, active individuals, leading to pain and issues, but there's limited research on factors influencing initial surgery for this condition.* -
- The study aimed to identify variables related to surgical intervention in shoulder instability patients using the FEDS classification system, which categorizes injuries by frequency, etiology, direction, and severity.* -
- Analysis of data from 377 treated patients revealed that younger age, recurrent instability, and sports-related injuries were linked to a higher likelihood of needing surgery, but the severity of dislocation did not significantly impact surgical outcomes.*
Background & Aims: Using a mouse model that reproduces major features of irritable bowel syndrome (long-lasting colon hypersensitivity without inflammation), we examined the contributions of 2 proteins, transient receptor potential vanilloid 1 (TRPV1) and acid-sensing ion channel 3 (ASIC3), on development of behavioral hypersensitivity and assessed the function of colon mechanoreceptors of hypersensitive mice.
Methods: Visceral nociceptive behavior was measured as the visceromotor response (VMR) to colorectal distention (CRD) before and after intracolonic treatment with zymosan or saline. Colon pathology was assessed in parallel experiments by quantifying myeloperoxidase activity, intralumenal pH, and tissue histology.