Publications by authors named "Emily Tam Nguyen"
Article Synopsis
- Alpha-14 giardin, part of the alpha giardin family related to annexins, localizes to the flagella of Giardia lamblia and is thought to be important for cytoskeletal changes during the parasite's differentiation.
- Researchers determined the three-dimensional structures of alpha-14 giardin in both apo and Ca(2+)-bound forms, revealing notable structural differences from its family member, alpha-11 giardin, and identifying a novel calcium-binding site.
- Alpha-14 giardin has a unique structure without N-terminal domains, and its binding properties indicate it interacts with phospholipids in a calcium-dependent manner, highlighting its potential role in cellular processes within the parasite.
Alpha-11 giardin is a member of the multi-gene alpha-giardin family in the intestinal protozoan, Giardia lamblia. This gene family shares an ancestry with the annexin super family, whose common characteristic is calcium-dependent binding to membranes that contain acidic phospholipids. Several alpha giardins are highly expressed during parasite-induced diarrhea in humans.
View Article and Find Full Text PDFExpression, purification, crystallization and preliminary X-ray diffraction analysis of alpha-11 giardin from Giardia lamblia.
Acta Crystallogr Sect F Struct Biol Cryst Commun
November 2006
Article Synopsis
- Alpha-11 Giardin is a protein from the Giardia lamblia parasite, known to cause giardiasis, a type of diarrhea.
- The study focuses on cloning, expressing, purifying, and crystallizing this protein under two different conditions, resulting in crystals that diffracted at different resolutions.
- Understanding the atomic structure of alpha-11 giardin may reveal its biological function and help assess its potential as a drug target for treating giardiasis.