Structural and Biochemical Characterization of Cysteine Desulfurase Complex SufSU.

In this work, we provide the first in vitro characterization of two essential proteins from (. ) involved in iron-sulfur (Fe-S) cluster biogenesis: the cysteine desulfurase SufS and the sulfurtransferase SufU. Together, these proteins form the transient SufSU complex and execute the first stage of Fe-S cluster biogenesis in the SUF-like pathway in Gram-positive bacteria.