Publications by authors named "Emily Szeto"
Confocal microscopy utilizing fluorescent dyes is widely gaining use in the clinical setting as a diagnostic tool. Reflectance confocal microscopy is a method of visualizing tissue specimens without fluorescent dyes while relying on the natural refractile properties of cellular and subcellular structures. We prospectively evaluated 76 CNS lesions with confocal reflectance microscopy (CRM) to determine cellularity, architecture, and morphological characteristics.
View Article and Find Full Text PDFThe basic helix-loop-helix (bHLH) transcription factor OLIG2 is a master regulator of oligodendroglial fate decisions and tumorigenic competence of glioma stem-like cells (GSCs). However, the molecular mechanisms underlying dysregulation of OLIG2 function during gliomagenesis remains poorly understood. Here, we show that OLIG2 modulates growth factor signaling in two distinct populations of GSCs, characterized by expression of either the epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha (PDGFRα).
View Article and Find Full Text PDFArticle Synopsis
- In glioblastoma, there's a crucial link between the phosphorylation state of the transcription factor OLIG2 and the tumor cells' ability to switch between growth and invasion.
- Unphosphorylated OLIG2 enhances cell migration and invasion by increasing TGF-β2 expression, while phosphorylated OLIG2 prevents this invasive behavior.
- Targeting the TGF-β2 pathway could be a potential strategy for treating glioblastoma by limiting the invasive capabilities of tumor cells.