Publications by authors named "Emily S Cheng"
Article Synopsis
- Unlabelled possesses a unique secretory system with specialized organelles essential for its life cycle, differing significantly from typical eukaryotic structures.
- The research identifies a crucial protein (ULP1) related to eukaryotic trafficking factors, whose depletion impacts parasite fitness by affecting key processes like invasion and replication.
- Eleven additional Golgi-associated proteins were discovered through proximity labeling, highlighting potential new targets for therapeutic development against apicomplexan parasites that impact human health.
Unlabelled: possesses a highly polarized secretory pathway that contains both broadly conserved eukaryotic organelles and unique apicomplexan organelles which play essential roles in the parasite's lytic cycle. As in other eukaryotes, the Golgi apparatus sorts and modifies proteins prior to their distribution to downstream organelles. Many of the typical trafficking factors found involved in these processes are missing from apicomplexan genomes, suggesting that these parasites have evolved unique proteins to fill these roles.
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