Publications by authors named "Emily R Siniscalco"
The increasing prevalence of food allergy and related pathologies in recent years has underscored the need to understand the factors affecting adverse reactions to food. Food allergy is caused when food-specific IgE triggers the release of histamine from mast cells. However, other food-specific antibody isotypes exist as well, including IgG and IgA.
View Article and Find Full Text PDFFood allergy is a growing problem with limited treatment options. It is important to understand the mechanisms of food tolerance and allergy to promote the development of directed therapies. Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that prime adaptive immune responses, such as those involved in the development of oral tolerance and food allergies.
View Article and Find Full Text PDFArticle Synopsis
- DOCK8 is a protein that helps the immune system function properly, especially in the gut, and its mutations can cause infections and weak responses to vaccines but high allergic reactions to food.
- In experiments with mice without DOCK8, it showed that this protein is needed for making a type of antibody (IgA) that protects the gut from certain things like peanuts and cholera.
- The study found that for IgA-producing cells to survive and work well in the gut, DOCK8 is really important, and these cells also have special energy needs to stay alive.
Low protease activity in the FDC network is crucial for intact antigen retention and has translational potential for more effective vaccination strategies.
View Article and Find Full Text PDFB cells produce acetylcholine that is sensed by bone marrow stromal cells and reduces hematopoiesis.
View Article and Find Full Text PDFComplement signaling on B cells affects germinal center dynamics.
View Article and Find Full Text PDF