Publications by authors named "Emily R Blevins"
Article Synopsis
- Researchers investigated protic ruthenium complexes with dihydroxybipyridine (dhbp) ligands and spectator ligands (like bpy and phen) to evaluate their effectiveness against cancer cells and their luminescent properties.
- The study focuses on 16 complexes derived from two protonation states (acidic and deprotonated), including new complexes that were synthesized and characterized through spectroscopy and X-ray crystallography.
- Key findings show that certain complexes can be activated by light to exhibit photocytotoxicity, with specific complex characteristics such as longer luminescent lifetimes correlating with improved effectiveness against cancer cells.
Nine ruthenium CNC pincer complexes (1-9) were tested for anticancer activity in cell culture under both dark and light conditions. These complexes included varied CNC pincer ligands including OH, OMe, or Me substituents on the pyridyl ring and wingtip N-heterocyclic carbene (NHC) groups which varied as methyl (Me), phenyl (Ph), mesityl (Mes), and 2,6-diisopropylphenyl (Dipp). The supporting ligands included acetonitrile, Cl, and 2,2'-bipyridine (bpy) donors.
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