Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells.

Background: Natural killer (NK) cells are being extensively studied as a cell therapy for cancer. These cells are activated by recognition of ligands and antigens on tumor cells. Cytokine therapies, such as IL-15, are also broadly used to stimulate endogenous and adoptively transferred NK cells in patients with cancer.

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells.

Background: NK cells are being extensively studied as a cell therapy for cancer. Their effector functions are induced by the recognition of ligands on tumor cells and by various cytokines. IL-15 is broadly used to stimulate endogenous and adoptively transferred NK cells in cancer patients.

CD8 T cell self-tolerance permits responsiveness but limits tissue damage.

Self-specific CD8T cells can escape clonal deletion, but the properties and capabilities of such cells in a physiological setting are unclear. We characterized polyclonal CD8 T cells specific for the melanocyte antigen tyrosinase-related protein 2 (Trp2) in mice expressing or lacking this enzyme (due to deficiency in , which encodes Trp2). Phenotypic and gene expression profiles of pre-immune Trp2/K-specific cells were similar; the size of this population was only slightly reduced in wild-type (WT) compared to -deficient () mice.

The virtuous self-tolerance of virtual memory T cells.

“Virtual” memory CD8 T cells are a subset of immune cells produced by homeostatic mechanisms involving response to self‐antigens, raising the possibility that these cells could mediate autoimmunity. New work by Drobek demonstrates that virtual memory T cells are indeed favored by stronger T‐cell receptor signals but exhibit minimal autoreactivity while maintaining self‐tolerance.