Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer without effective treatments. It is characterized by activating KRAS mutations and p53 alterations. However, how these mutations dysregulate cancer-cell-intrinsic gene programs to influence the immune landscape of the tumor microenvironment (TME) remains poorly understood.

A closer examination of the "rural mortality penalty": Variability by race, region, and measurement.

Background: Racial health disparities are well documented and pervasive across the United States. Evidence suggests there is a "rural mortality penalty" whereby rural residents experience poorer health outcomes than their urban counterparts. However, whether this penalty is uniform across demographic groups and U.

Caregivers' Role in In-Home Video Telehealth: National Survey of Occupational Therapy Practitioners.

Background: Older adults face barriers to specialty care, such as occupational therapy (OT), and these challenges are worse for rural older adults. While in-home video telehealth may increase access to OT, older adults' health- and technology-related challenges may necessitate caregiver assistance.

Objective: This study examines caregiver assistance with in-home OT video telehealth visits from the perspectives of OT practitioners at Veterans Health Administration (VHA).

Caregiver Support Role in Occupational Therapy Video Telehealth: A Scoping Review.

Caregiver involvement may facilitate patient participation in occupational therapy (OT) video telehealth. However, little is known about the extent to which caregivers participate and what they do. This scoping review aims to, 1) describe the caregiver role supporting patient participation in OT video telehealth, and, 2) identify barriers and facilitators to caregiver involvement.

Using Nudges to Reduce Missed Appointments in Primary Care and Mental Health: a Pragmatic Trial.

Background: Missed appointments ("no-shows") are a persistent and costly problem in healthcare. Appointment reminders are widely used but usually do not include messages specifically designed to nudge patients to attend appointments.

Objective: To determine the effect of incorporating nudges into appointment reminder letters on measures of appointment attendance.

Transcription factor antagonism regulates heterogeneity in embryonic stem cell states.

Gene expression heterogeneity underlies cell states and contributes to developmental robustness. While heterogeneity can arise from stochastic transcriptional processes, the extent to which it is regulated is unclear. Here, we characterize the regulatory program underlying heterogeneity in murine embryonic stem cell (mESC) states.

Occupational Therapy Practitioner Perspectives of the Role of Caregivers in Video Telehealth.

The current article examines the role of caregivers to support patient participation in video telehealth, using data from interviews with occupational therapy practitioners at Veterans Health Administration. We found that caregiver participation allowed patients who might otherwise not be able to access video telehealth to do so, with patient factors, such as low technical literacy, contributing to caregiver involvement. In addition, caregiver participation varied by type of task performed.

Applying user-centered design in the development of nudges for a pragmatic trial to reduce no-shows among veterans.

Objective: To incorporate user-centered design processes into the refinement of nudges designed to reduce no-shows among healthcare appointments for military veterans in the Veterans Health Administration (VA).

Methods: We developed candidate nudges as brief messages based on four broad concepts in behavioral science. We then conducted iterative waves of multi-stage interviews (N = 27) that included a pile sorting task, a "think-aloud" review of each message, and prototype letter reviews.

Enhancing Usability of Appointment Reminders: Qualitative Interviews of Patients Receiving Care in the Veterans Health Administration.

Background: No-shows are a persistent and costly problem in all healthcare systems. Because forgetting is a common cause of no-shows, appointment reminders are widely used. However, qualitative research examining appointment reminders and how to improve them is lacking.

Changes in Fatigue Are the Same for Trained Men and Women after Resistance Exercise.

Purpose: To measure changes in fatigue and knee-extensor torque in the 48 h after trained men and women completed a full-body resistance exercise session.

Methods: Eight trained women (mean ± SD: age, 25.6 ± 5.

Trained females exhibit less fatigability than trained males after a heavy knee extensor resistance exercise session.

Purpose: We examined differences between trained males and females in measures of muscular fatigability and central motor output after a resistance exercise session.

Methods: Sixteen trained males (n = 8) and females (n = 8) participated in the study. Knee extensor maximal torque and rate of torque development were measured before and after the exercise session, and the twitch interpolation technique was used during the maximal efforts to derive measures of voluntary activation and muscle contractility by supramaximal stimulation of the femoral nerve using 10 and 100 Hz doublets.