Publications by authors named "Emily M Lachtara"
MYB fusions are recurrently found in select cancers, including blastic plasmacytoid DC neoplasm (BPDCN), an acute leukemia with poor prognosis. They are markedly enriched in BPDCN compared with other blood cancers and, in some patients, are the only obvious somatic mutation detected. This suggests that they may alone be sufficient to drive DC transformation.
View Article and Find Full Text PDFThe roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays a crucial role to regulate PARP1-mediated poly ADP-ribosylation (PARylation) and the choice of DSB repair pathways at sites of R-loops. Through bisulfite sequencing, we discover that the methyltransferase TRDMT1 preferentially generates m5C after DNA damage in R-loops across the genome.
View Article and Find Full Text PDFArticle Synopsis
- Cancer involves changes in how certain genes are turned on or off, and researchers found areas in DNA that are less active (hypomethylated) from early cancer stages to when it spreads.
- They discovered 40 key areas in the DNA that remain less active while some other smaller areas that help cells grow are still active.
- Some of the turned-off genes are important for the immune system, and turning them back on in mice can stop tumor growth and boost the immune response against cancer.