In-person and remote administrations of the symbol digit modalities test are interchangeable among persons with multiple sclerosis.

Background: Remote administration of the Symbol Digit Modalities Test (SDMT) requires validation.

Objectives: Examine interchangeability of remote and in-person SDMT administrations in persons with MS.

Methods: After in-person baseline administration, follow-up administration was either performed in-person (n = 72) or remotely via videoconferencing (n = 143).