Weekly observations of online survey metadata obtained through home computer use allow for detection of changes in everyday cognition before transition to mild cognitive impairment.

Introduction: Subtle changes in instrumental activities of daily living often accompany the onset of mild cognitive impairment (MCI) but are difficult to measure using conventional tests.

Methods: Weekly online survey metadata metrics, annual neuropsychological tests, and an instrumental activity of daily living questionnaire were examined in 110 healthy older adults with intact cognition (mean age = 85 years) followed up for up to 3.6 years; 29 transitioned to MCI during study follow-up.

Diagnostic Discrepancies in Retinopathy of Prematurity Classification.

Purpose: To identify the most common areas for discrepancy in retinopathy of prematurity (ROP) classification between experts.

Design: Prospective cohort study.

Participants: A total of 281 infants were identified as part of a multicenter, prospective, ROP cohort study from 7 participating centers.