Publications by authors named "Emily L Burke"
The most prevalent psychoactive chemical in tobacco smoke is nicotine, which has been shown to maintain tobacco consumption as well as cause acute adverse effects at high doses, like nausea and emesis. Recent studies in laboratory animals have suggested that many non-nicotine constituents of tobacco smoke (e.g.
View Article and Find Full Text PDFThe synthetic forms of delta-9-tetrahydrocannabinol (Δ-THC), dronabinol or nabilone, have been approved to treat several indications. However, due to safety concerns their clinical utility remains limited. Consequently, there is a need for developing cannabinoid (CB) ligands that display better behavioral pharmacological profiles than Δ-THC.
View Article and Find Full Text PDFArticle Synopsis
- - The U.S. opioid crisis, exacerbated by fentanyl, leads to over 70,000 overdose deaths each year, highlighting the urgent need for new treatments.
- - Researchers present CSX-1004, a fully human monoclonal antibody that effectively reverses fentanyl's pain-relieving and respiratory-depressing effects in animal models, showing a promising safety profile.
- - In non-human primate studies, CSX-1004 significantly reduces the potency of fentanyl effects for several weeks without interfering with other opioids like oxycodone, suggesting it could be a valuable tool in overdose prevention and treatment.
Since the early 2000s, studies have shown that the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections in the pediatric population has been increasing. Moreover, studies also have indicated a trend toward increased resistance to commonly used antibiotics over time. However, few studies have specifically focused on such trends in pediatric neck abscesses.
View Article and Find Full Text PDFCommon agents used to unblock blood clots within tympanostomy tubes: an ex vivo study and review of literature.
Int J Pediatr Otorhinolaryngol
December 2009
Objectives: To determine the efficacy of common solutions used to dissolve blood clots blocking tympanostomy tubes (TTs) of differing lengths and diameters.
Study Design: An ex vivo experimental study.
Methods: Ear models were built by the study investigator.
Objective: To update the outcome of hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma (TLAN) surgery.
Patients: One hundred eight previously reported patients undergoing abdominal fat graft reconstruction versus hydroxyapatite cement cranioplasty with additional 4-year follow up. Ninety additional patients undergoing a uniform technique of hydroxyapatite cement cranioplasty after TLAN.